Synergic effect of corneal hysteresis and central corneal thickness in the risk of early-stage primary open-angle glaucoma progression

To evaluate corneal hysteresis (CH), acquired with ocular response analyzer (ORA), as a risk factor for glaucoma progression in early-stage primary open-angle (POAG). In historical cohort study, patients diagnosed 2011 POAG according to the Hodapp, Parrish and Anderson classification modified Octopus perimetry followed up until glaucomatous development; otherwise, observations were censored October 2018. Cox regression was used obtain hazard ratios (HR) baseline variables (CH, central thickness, gender, age IOP family history) factors perimetric progression. A likelihood ratio test interaction performed order assess effect of combination CH CCT on Of 1573 patients, 11.38% developed during follow-up. The mean follow-up time 3.28 ± 1.92 years. Patients without had higher (11.35 1.43 vs 9.07 1.69 mmHg; p < 0.001) (570.75 17.71 554.51 23.20; 0.001). multivariate analysis, each 1 mmHg lower associated an increase 2.13 times HR (95% CI: 1.92–2.32; by CCT, values resulting early (p can be considered POAG. changed depending values, acting synergistically slowing values.